Domino alkylation/oxa-Michael of 1,3-cyclohexanediones: steering the C/O-chemoselectivity to reach tetrahydrobenzofuranones.
نویسندگان
چکیده
An unprecedented domino synthesis of tetrahydrobenzofuran-4-ones is described implicating chemoselective alkylation of various 1,3-cyclohexanediones with bromocrotonate or crotonitrile followed by oxa-Michael cyclization. Further transformations of this core to reach molecular diversity are also presented.
منابع مشابه
Uncatalyzed Synthesis of Arylmethylene[bis(5,5-dimethyl-3-hydroxy-2-cyclohexene-1-ones)] in Hot Water by Domino Knoevenagel/Michael Reactions
A simple and ecofriendly method was developed for the synthesis of arylmethylene[bis(5,5- dimethyl-3-hydroxy-2-cyclohexene-1-ones)] from the reaction of 5,5-dimethylcyclohexane- 1,3-dione and aromatic aldehydes in an aqueous media without any catalyst via Knoevenagel condensation followed by rapid Michael addition. No cyclization product was down to convert these enolic forms to xanthene deriva...
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 19 شماره
صفحات -
تاریخ انتشار 2011